Your skin already has the extraordinary ability to repair itself. Rejuran is designed to make the most of it. A cutting-edge injectable skin-boosting treatment formulated with salmon-derived polynucleotides, Rejuran has built a committed following across South Korea, Europe and beyond for its ability to address stubborn signs of aging and skin damage at the cellular level.
At the practice of Dr. Glenn Vallecillos in Beverly Hills, Rejuran is offered as part of a broader, physician-directed approach to skin health that goes well beyond the surface of the skin. Whether you’re noticing fine lines, dullness, dehydration or a general loss of skin resilience, Rejuran offers a science-backed path to renewal that works with your body’s own regenerative biology.
What Is Rejuran and How Does It Work?
Rejuran is an injectable skin booster formulated with a highly purified concentration of polynucleotides (PN), which are short chains of nucleotides. In this case, the polynucleotides are extracted from salmon DNA, which is very similar in structure to human DNA. This makes Rejuran highly absorbable and well-tolerated by the body.
When Rejuran is injected into the deeper tissue layers (dermis), it triggers a cascade of powerful healing processes that repair the skin. This response includes the activation of fibroblasts, which are cells responsible for producing collagen and elastin to support tissue remodeling and healing.
A 2024 review in the International Journal of Molecular Sciences is one of several that concluded polynucleotides have a high potential for stimulating collagen, improving skin elasticity, fading wrinkles and doing so with an excellent safety profile. The focus on collagen means that while some early results may be visible, they will continue to improve for as long as six months while your skin rebuilds and remodels.
Why So Many Patients Are Choosing Rejuran
Thanks to its ability to promote deep skin remodeling with a minimally invasive approach, Rejuran is uniquely positioned among even today’s highly competitive selection of surgical and non-surgical aesthetic treatments.
Dr. Vallecillos’s patients choose Rejuran because:
It addresses root causes, not just symptoms. Where traditional fillers add volume and neurotoxins relax muscle activity, Rejuran works at the cellular level to improve the actual quality of the skin.
It covers a wide range of common skin issues. Sometimes, even with high-quality options available, trying to address all your concerns in one treatment plan can be overwhelming. Rejuran offers an answer to patients dealing with a combination of fine lines and early wrinkles, uneven skin texture, enlarged pores, dullness, chronic dehydration, acne scarring or skin laxity.
It works well in combination. Rejuran can be layered with other treatments at Dr. Vallecillos’s practice to amplify results. Pairing it with Fraxel or microneedling speeds up healing between treatments while boosting collagen activity even further. It can also complement FaceTite or BodyTite treatments where skin tightening is the primary goal.
Recovery is minimal. Most patients experience mild redness, small injection-site papules and perhaps light swelling immediately after the procedure. These effects typically resolve within 24 to 72 hours. There’s no extended downtime, no disruption to daily life and no bandages or incisions involved.
Am I a Good Candidate for Rejuran?
While Rejuran is a highly inclusive treatment in that it is gentle, well-tolerated and versatile, there are still some factors that may make you more or less well-suited for this treatment.
You may be an ideal candidate for Rejuran if you:
- Are in your late 20s or older and are noticing the early signs of collagen loss, such as fine lines, large pores or a loss of natural dewiness
- Have dry, dehydrated or dull skin that hasn’t responded well to topical approaches
- Are dealing with residual acne scarring, uneven texture or hyperpigmentation
- Want to complement or maintain results from a surgical procedure like a facelift or blepharoplasty
- Have sensitive or reactive skin and want an effective treatment with a strong tolerability profile
Rejuran is not recommended for patients who are pregnant or breastfeeding, have known allergies to salmon or seafood, or are currently taking certain blood-thinning medications or immunosuppressants. Dr. Vallecillos will conduct a thorough skin assessment and review your complete medical history at your consultation to determine your candidacy.
After Rejuran: What You Need to Know
Immediately after treatment, it’s normal to notice some small raised papules at the injection sites, mild redness and a degree of swelling. These resolve within one to three days, though any mild bruising present in the area may linger for slightly longer.
In the weeks following your session, your skin is in the process of remodeling itself. Fibroblast activity increases, collagen fibers begin to reorganize and hydration levels improve as the skin’s barrier function strengthens. Most patients notice a meaningful improvement in texture by the four-week mark, which progresses steadily from there.
For the best results, use sun protection, stay hydrated, avoid any supplements or medications as directed, and prioritize gentle skincare for the first day (at least) after treatment.
Why Choose Dr. Vallecillos for Rejuran Treatment?
Though Rejuran isn’t a surgical procedure, precise injection technique, depth placement and volume distribution are still crucial factors that separate stellar results from average results. This is why you need a highly skilled and experienced provider with a deep understanding of the skin and how it will respond to treatment.
Dr. Glenn Vallecillos, MD, FACS is a board-certified Beverly Hills plastic surgeon whose expertise spans both surgical and nonsurgical facial aesthetics. His credentials include:
- Senior Faculty Member of Palette/Scientiae, providing continuing medical education to nurses, PAs, physicians and surgeons across the United States
- Contributor to the European Journal of Plastic Surgery
- Advisory board member for Allergan, Suneva and Hans Biomed
- The first plastic surgeon in the world to combine VASER-assisted high-definition lipoplasty with Inmode’s RFAL FaceTite and Bodytite platforms
Rather than offering it as an isolated procedure, Dr. Vallecillos evaluates each patient’s full facial aesthetic picture and determines how Rejuran fits into a comprehensive, customized plan. If you are thinking about fat transfer to the face, lip augmentation or a nonsurgical skin-tightening option like Sculptra, Rejuran can be layered into the strategy for truly powerful and well-rounded results.
Your Skin, Re-Engineered
You are more empowered than ever to take control of your skin health and gracefully combat early signs of aging, thanks to innovative tools like Rejuran. If you’re ready to see what your skin looks like when it’s working at full strength, contact the office of Dr. Glenn Vallecillos today to schedule your consultation.
Call us at (310) 273-3007 to get started.
Frequently Asked Questions
How is Rejuran different from dermal fillers or Botox?
Fillers add volume to specific areas, and neurotoxins like Botox temporarily relax the muscles responsible for expression lines. Rejuran improves the fundamental quality and health of the skin itself by stimulating collagen production, restoring hydration and supporting cellular repair. It doesn’t fill or freeze; it regenerates. Rejuran is often used alongside these treatments rather than as a direct replacement, since they address different dimensions of facial aging.
How many Rejuran sessions will I need?
Most patients begin with an initial series of three to four sessions scheduled approximately four weeks apart. This course establishes the collagen-stimulating and tissue-repair response. Maintenance sessions every three to six months thereafter help preserve and build on those gains. Your specific protocol will be determined by Dr. Vallecillos based on your skin condition and goals.
Is there downtime after Rejuran treatment?
Downtime is minimal. Most patients are comfortable returning to their normal activities the following day. The first 24 hours post-treatment call for a gentle skincare routine and avoidance of active ingredients, exercise and sun exposure.
Can Rejuran be combined with other treatments at Dr. Vallecillos’s practice?
Yes, and it often performs best when it’s integrated into a broader plan. Rejuran pairs well with laser treatments like Fraxel and Clear + Brilliant, as the polynucleotides support post-laser recovery while improving collagen remodeling. It can also complement FaceTite, microneedling and surgical procedures. Dr. Vallecillos will advise on sequencing and timing to maximize the benefit of each treatment in your plan.
Who is not a good candidate for Rejuran?
Pregnant or breastfeeding women, patients with known seafood or fish allergies, patients who are taking anticoagulant medications, or those with autoimmune conditions or active skin infections near the treatment area may be advised to avoid Rejuran. Note that this is not an exhaustive list, and a consultation with Dr. Vallecillos is always the best way to clearly confirm your candidacy.
When will I see full results from Rejuran?
Because Rejuran works by stimulating the skin’s own regenerative processes, results develop gradually rather than appearing immediately. Most patients notice improvements in skin texture and hydration within three to four weeks. More significant changes in firmness, pore size and fine lines continue to develop over three to six months as collagen production increases and the skin’s internal structure rebuilds.